Important information before starting treatment with IMCIVREE


Actor portrayals
How do I take IMCIVREE?
How is IMCIVREE injected?
Because IMCIVREE is injected just under the skin, the needle is short and thin (only a half-inch long).
- You can receive training on how to prepare and administer IMCIVREE before you inject on your own; training can be given by your doctor or coordinated through Rhythm InTune
Understanding dosing
- Each vial of IMCIVREE contains enough medicine for more than one dose; the number of doses in each vial will depend on the dose prescribed by your healthcare provider
- Please note that the vial will not be full of medicine; only fill the syringe with the amount of IMCIVREE needed for your prescribed dose
- Dispose of any leftover medicine
Do not combine vials of IMCIVREE for the injection. Use one vial that contains enough medicine for the prescribed dose.


Watch the video to see a demonstration on how to inject IMCIVREE at home.
The first time I gave him an injection, he was scared and thought it was going to hurt. But now it doesn’t faze him at all.
– Caregiver of a child taking IMCIVREE
Individual results may vary.
Achieving the benefits of IMCIVREE may take time
Some people in the clinical trials experienced certain side effects soon after starting treatment, and most of these declined or leveled off after the first month of treatment.
Staying on IMCIVREE is important to maintain long-term reductions in weight and hunger
This chart highlights some of the most common side effects, but it does not include all reported side effects.

- Meaningful weight reduction as measured by BMI began within 6 to 8 weeks of starting treatment and continued over time
- Hunger reduction began within weeks; measures of hunger increased quickly upon dose reduction or discontinuation of IMCIVREE
- Nausea and vomiting were primarily reported within the first 4 weeks of treatment and typically went away within a few days; nearly all events were mild, and none were severe
- Skin darkening generally appeared within the first month of starting IMCIVREE; it usually leveled off within the initial months, then remained stable over long-term treatment
Nausea and vomiting are some of the common side effects of IMCIVREE. There are other side effects reported with IMCIVREE that may occur within the first ~90 days of treatment or later.
Talk to your doctor about any side effects you experience while on treatment with IMCIVREE.
Support throughout your IMCIVREE journey
Maintaining a consistent dosing schedule is important. Your Rhythm InTune Patient Education Manager (PEM)* can provide injection education and help you understand your medication.
*Patient Education Managers are employees of Rhythm Pharmaceuticals and do not provide medical care or advice. We encourage you to always speak to your healthcare providers regarding your medical care.
Learn more about how to give IMCIVREE.
Explore the resource library for additional support and information.