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Resources and support for your IMCIVREE journey

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Personalized support throughout your journey

Rhythm InTune Patient Education Manager (PEM) - Kristina

KristinaRhythm InTune Patient Education Manager (PEM)

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Whether you're learning about POMC, PCSK1, or LEPR deficiency, preparing for a visit, or managing daily routines, a Rhythm InTune Patient Education Manager (PEM)* can provide resources, education, and information.

Connect With a Patient Education Manager

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Download and fill out a Patient Consent Form to enroll in Rhythm InTune.

Patient Education Managers

Patient Education Managers can help you with:

  • Coverage and Financial Assistance: Help you understand your insurance coverage and explain financial assistance options for eligible patients
  • Injection Training: Provide virtual or live injection training and educational materials
  • Starting Treatment: Provide education on what to expect when you start treatment and possible side effects
  • Accessing Educational Resources: Provide a library of resources with information about POMC, PCSK1, or LEPR deficiency and treatment with IMCIVREE

If you’re interested in speaking with a Patient Education Manager about the education and support Rhythm InTune can offer you or the person you care for, you can call or email us at 1-855-206-0815 (M-F, 8am-6pm ET) or patientsupport@rhythmtx.com.

*Patient Education Managers are employees of Rhythm Pharmaceuticals and do not provide medical care or advice. We encourage you to always speak to your healthcare providers regarding your medical care.

Helpful Resources

Here are some available resources to support you throughout your treatment with IMCIVREE.

About IMCIVREE

PPL Patient Brochure Thumbnail

IMCIVREE Brochure

Includes information about IMCIVREE, such as clinical trial results and side effects, for those who are interested in learning more or are considering starting treatment

Download PDF

Support From Rhythm InTune

Rhythm InTune Brochure Thumbnail

Rhythm InTune Brochure

A brochure detailing the personalized support, education, resources, and information that Rhythm InTune offers to people living with certain forms of rare obesity

Download PDF (English)Download PDF (Spanish)
Rhythm InTune Starting on Treatment Guide Thumbnail

Starting on Treatment Guide

A step-by-step guide for patients and caregivers outlining what you need to know when starting treatment and how Rhythm InTune can help you through the process

Download PDF (English)Download PDF (Spanish)
Woman on couch speaking about her Rhythm InTune experience

My Rhythm InTune Experience

Hear from people who have experienced the benefits of working with a Patient Education Manager every step of the way

Ongoing Treatment With IMCIVREE

IMCIVREE Patient Injection Guide Thumbnail

IMCIVREE Injection Guide

A step-by-step guide that includes everything you need to know about giving an IMCIVREE injection

Download PDF (English)Download PDF (Spanish)
Rhythm InTune Patient Wellness Brochure Thumbnail

Rhythm InTune Wellness Brochure

A brochure that provides wellness tips for people living with a rare genetic disease that causes obesity

Download PDF (English)Download PDF (Spanish)
IMCIVREE Patient Treatment Journal Thumbnail

IMCIVREE Treatment Journal

A journal that helps you track treatment by recording when and where IMCIVREE was injected each day, as well as any important notes you may want to remember to tell your doctor

Download PDF (English)Download PDF (Spanish)

How to Inject IMCIVREE

This video demonstrates how to inject and store your medicine.

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Resources for your treatment journey

Wherever you are in your journey, your Rhythm InTune Patient Education Manager (PEM)† can provide the resources and support you need to help you feel prepared and informed.

Get Connected

†Patient Education Managers are employees of Rhythm Pharmaceuticals and do not provide medical care or advice. We encourage you to always speak to your healthcare providers regarding your medical care.

Get answers to frequently asked questions about IMCIVREE.

See FAQ

What is IMCIVREE?

IMCIVREE is a prescription medicine used in adults and children 2 years of age and older with obesity due to the genetic conditions pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiency, to help them lose weight and keep the weight off.

Your healthcare provider should order a genetic test to confirm POMC, PCSK1, or LEPR deficiency before you start using IMCIVREE.

IMCIVREE is not for use in people with the following conditions because it may not work:

  • Obesity due to suspected POMC, PCSK1, or LEPR deficiency not confirmed by genetic testing or with benign or likely benign genetic testing results
  • Other types of obesity not related to POMC, PCSK1, or LEPR deficiency, or other FDA-approved uses of IMCIVREE, including obesity associated with other genetic conditions and general obesity

It is not known if IMCIVREE is safe and effective in children under 2 years of age.

Important Safety Information

Do not use IMCIVREE if you have had a serious allergic reaction to it or any of its ingredients. Serious allergic reactions, including anaphylaxis, can happen.

Before you use IMCIVREE, tell your healthcare provider about all your medical conditions, including if you:

  • Have or have had areas of darkened skin, including skin discoloration (hyperpigmentation)
  • Have or have had depression, or suicidal thoughts or behavior
  • Have kidney problems
  • Are pregnant or planning to become pregnant. Losing weight while pregnant may harm your unborn baby. Your healthcare provider may stop your treatment with IMCIVREE if you become pregnant. Tell your healthcare provider if you become pregnant or think you might be pregnant during treatment with IMCIVREE
  • Are breastfeeding or plan to breastfeed. It is not known if IMCIVREE passes into your breast milk. You should not breastfeed during treatment with IMCIVREE

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

See the detailed Instructions for Use that come with your IMCIVREE to learn how to prepare and inject IMCIVREE, and how to properly throw away (dispose of) used syringes and needles.

What are the possible side effects of IMCIVREE?
IMCIVREE may cause serious side effects, including:

  • Male and female sexual function problems. IMCIVREE can cause an erection that happens without any sexual activity in males (spontaneous penile erection) and unwanted sexual reactions (changes in sexual arousal that happen without any sexual activity) in females. If you have an erection lasting longer than 4 hours, get emergency medical help right away
  • Depression and suicidal thoughts or actions. You or a caregiver should call your healthcare provider right away if you have any new or worsening symptoms of depression, suicidal thoughts or behaviors, or any unusual changes in mood or behavior
  • Serious allergic reactions. Stop taking IMCIVREE and get medical help right away if you have any symptoms of a serious allergic reaction including: swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; rapid heartbeat
  • Increased skin pigmentation, darkening of skin lesions (moles or nevi) you already have, and development of new skin lesions. These changes happen because of how IMCIVREE works in the body and will go away when you stop using IMCIVREE. You should have a full body skin exam before starting and during treatment with IMCIVREE to check for skin changes

The most common side effects of IMCIVREE include darkening of the skin, injection site reactions, nausea, headache, diarrhea, stomach pain, vomiting, depression, and an erection that happens without any sexual activity in males.

These are not all the possible side effects of IMCIVREE. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to FDA. Visit www.fda.gov/medwatch or call FDA at 1-800-FDA-1088.

Please see full Prescribing Information, including Patient Information.

Use and Important Safety Information

What is IMCIVREE?

IMCIVREE is a prescription medicine used in adults and children 2 years of age and older with obesity due to the genetic conditions pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiency, to help them lose weight and keep the weight off.

Your healthcare provider should order a genetic test to confirm POMC, PCSK1, or LEPR deficiency before you start using IMCIVREE.

IMCIVREE is not for use in people with the following conditions because it may not work:

  • Obesity due to suspected POMC, PCSK1, or LEPR deficiency not confirmed by genetic testing or with benign or likely benign genetic testing results
  • Other types of obesity not related to POMC, PCSK1, or LEPR deficiency, or other FDA-approved uses of IMCIVREE, including obesity associated with other genetic conditions and general obesity

It is not known if IMCIVREE is safe and effective in children under 2 years of age.

Important Safety Information

Do not use IMCIVREE if you have had a serious allergic reaction to it or any of its ingredients. Serious allergic reactions, including anaphylaxis, can happen.

Before you use IMCIVREE, tell your healthcare provider about all your medical conditions, including if you:

  • Have or have had areas of darkened skin, including skin discoloration (hyperpigmentation)
  • Have or have had depression, or suicidal thoughts or behavior
  • Have kidney problems
  • Are pregnant or planning to become pregnant. Losing weight while pregnant may harm your unborn baby. Your healthcare provider may stop your treatment with IMCIVREE if you become pregnant. Tell your healthcare provider if you become pregnant or think you might be pregnant during treatment with IMCIVREE
  • Are breastfeeding or plan to breastfeed. It is not known if IMCIVREE passes into your breast milk. You should not breastfeed during treatment with IMCIVREE

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

See the detailed Instructions for Use that come with your IMCIVREE to learn how to prepare and inject IMCIVREE, and how to properly throw away (dispose of) used syringes and needles.

What are the possible side effects of IMCIVREE?
IMCIVREE may cause serious side effects, including:

  • Male and female sexual function problems. IMCIVREE can cause an erection that happens without any sexual activity in males (spontaneous penile erection) and unwanted sexual reactions (changes in sexual arousal that happen without any sexual activity) in females. If you have an erection lasting longer than 4 hours, get emergency medical help right away
  • Depression and suicidal thoughts or actions. You or a caregiver should call your healthcare provider right away if you have any new or worsening symptoms of depression, suicidal thoughts or behaviors, or any unusual changes in mood or behavior
  • Serious allergic reactions. Stop taking IMCIVREE and get medical help right away if you have any symptoms of a serious allergic reaction including: swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; rapid heartbeat
  • Increased skin pigmentation, darkening of skin lesions (moles or nevi) you already have, and development of new skin lesions. These changes happen because of how IMCIVREE works in the body and will go away when you stop using IMCIVREE. You should have a full body skin exam before starting and during treatment with IMCIVREE to check for skin changes

The most common side effects of IMCIVREE include darkening of the skin, injection site reactions, nausea, headache, diarrhea, stomach pain, vomiting, depression, and an erection that happens without any sexual activity in males.

These are not all the possible side effects of IMCIVREE. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to FDA. Visit www.fda.gov/medwatch or call FDA at 1-800-FDA-1088.

Please see full Prescribing Information, including Patient Information.

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