In children and adults 6 years of age and older with obesity due to POMC, PCSK1, or LEPR deficiency
IMCIVREE delivered weight and hunger reduction over 1 year
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IMCIVREE reduced weight in children and adults 6 years of age and older with obesity due to POMC or PCSK1 deficiency
This study included 10 children and adults 6 years of age and older.
8 out of 10 people lost at least 10% of their body weight at 1 year
Average weight change over 1 year (n=9)*
Weight loss with IMCIVREE continued over the year, except during the withdrawal period. When treatment was restarted, weight loss resumed.
From visits 6-8, participants went through a withdrawal period of 8 weeks, which included 4 weeks of IMCIVREE followed by 4 weeks of no treatment. Neither the investigators nor the participants were aware of when the 4-week non-treatment time period was occurring.
*Participants who experienced weight loss of 5 kg/11 lb (or 5% if their starting weight was less than 100 kg/220 lb) during the first 10 weeks.
IMCIVREE reduced feelings of hunger over 1 year
After 1 year, participants 12 and older with obesity due to POMC or PCSK1 deficiency (n=8) experienced a decrease from 7.9 to 5.5 in the median† daily hunger score.
Changes in hunger were evaluated using a questionnaire that was completed each day for 1 year by participants who were 12 years of age or older. The questionnaire measured hunger using a score ranging from 0 ("not hungry at all") to 10 ("hungriest possible").
Impact of stopping treatment
Treatment was stopped for a period of time to see how it impacted weight and hunger. Over this withdrawal period:
- Weight increased; when the withdrawal period ended and treatment was restarted, weight loss continued
- Hunger scores generally worsened; hunger scores improved once treatment was restarted
†A median is the middle value of a set of data that have been put into numerical order. The median is the value that divides the data into two halves.
IMCIVREE reduced weight in children and adults 6 years of age and older with obesity due to LEPR deficiency
This study included 11 children and adults 6 years of age and older.
5 out of 11 people lost at least 10% of their body weight at 1 year
Average weight change over 1 year (n=7)‡
Weight loss with IMCIVREE continued over the year, except during the withdrawal period. When treatment was restarted, weight loss resumed.
From visits 6-8, participants went through a withdrawal period of 8 weeks, which included 4 weeks of IMCIVREE followed by 4 weeks of no treatment. Neither the investigators nor the participants were aware of when the 4-week non-treatment time period was occurring.
‡Participants who experienced weight loss of 5 kg/11 lb (or 5% if their starting weight was less than 100 kg/220 lb) during the first 10 weeks.
IMCIVREE reduced feelings of hunger over 1 year
After 1 year, participants 12 and older with obesity due to LEPR deficiency (n=8) experienced a decrease from 7.0 to 4.4 in the median§ daily hunger score.
Changes in hunger were evaluated using a questionnaire that was completed each day for 1 year by participants who were 12 years of age or older. The questionnaire measured hunger using a score ranging from 0 ("not hungry at all") to 10 ("hungriest possible").
Impact of stopping treatment
Treatment was stopped for a period of time to see how it impacted weight and hunger. Over this withdrawal period:
- Weight increased; when the withdrawal period ended and treatment was restarted, weight loss continued
- Hunger scores generally worsened; hunger scores improved once treatment was restarted
§A median is the middle value of a set of data that have been put into numerical order. The median is the value that divides the data into two halves.
A lot has changed, and when I look at the hunger today, I’m assuming it’s on the same level as other people.
– Person who is living with POMC deficiency
I’m very satisfied I’ve lost a lot of weight, and I have a lot more energy. It’s nice to see that someone is paying attention to this, and there’s a medication for this.
– Person who is living with POMC deficiency
Now, I really feel it. My stomach growls and I notice that I am hungry. Experiencing both fullness and hunger is something I have never felt before. It's funny.
– Person who is living with LEPR deficiency
Individual results may vary.
Resources and support tailored to your journey
Rhythm InTune Patient Education Managers (PEMs)¶ offer personalized educational resources designed around your treatment journey. From providing disease education to helping you stay on track with treatment, your PEM is here to support you or your loved one.
¶Patient Education Managers are employees of Rhythm Pharmaceuticals and do not provide medical care or advice. We encourage you to always speak to your healthcare providers regarding your medical care.
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